![]() ![]() Through natural evolution and structural modeling, we identified host-range-determining regions (HRDRs) in the T3 phage tail fiber protein and developed a high-throughput strategy to genetically engineer these regions through site-directed mutagenesis. However, acquisition of resistance by bacteria is a major issue in the successful development of phage therapies. The rapid emergence of antibiotic-resistant infections is prompting increased interest in phage-based antimicrobials.
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